Doc Hollywood

Michael J. Fox

Benjamin Stone

Julie Warner

Vialula (Lou)

Barnard Hughes

Aurelius Hogue

Woody Harrelson

Hank Gordon

David Ogden Stiers

Mayor Nick Nicholson

Frances Sternhagen

Lillian, Welcoming Committee

George Hamilton

Doctor Halberstrom

Bridget Fonda

Nancy Lee Nicholson

Mel Winkler

Melvin the Mechanic

Helen Martin

Maddie, Welcoming Committee

Roberts Blossom

Judge Evans

Tom Lacy

Deputy Cotton

Macon McCalman

Aubrey Draper

Raye Birk

Simon Tidwell, First Patient

Eyde Byrde

Nurse Packer

William Cowart

Lane, Melvin's Helper