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Richard Pryor

Eddie Lenahan/Dr. Kevin Slattery

Rachel Ticotin

Rachel Atwood

Rubén Blades

Louis

Maria Cardinale

Herself

Joe Mantegna

Arthur Chambers

Bob Dishy

Dr. Foster

Sylvia Miles

Nurse Maggie Lesser

Joe Dallesandro

Stucky

Randall 'Tex' Cobb

Box

Bob Saget

Dr. Joffe

Jon Polito

Kline

Garrett Morris

Helicopter Junkie

Brian Tarantina

Tommy Pinto

Jude Ciccolella

Jack Kinney

Elizabeth Arlen

E.R. Nurse

Wesley Snipes

Ambulance Driver